Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics
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چکیده
منابع مشابه
Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics
Protein thermodynamics are an integral determinant of viral fitness and one of the major drivers of protein evolution. Mutations in the influenza A virus (IAV) hemagglutinin (HA) protein can eliminate neutralizing antibody binding to mediate escape from preexisting antiviral immunity. Prior research on the IAV nucleoprotein suggests that protein stability may constrain seasonal IAV evolution; h...
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ژورنال
عنوان ژورنال: mSphere
سال: 2018
ISSN: 2379-5042
DOI: 10.1128/mspheredirect.00554-17